PoplarV1, Main, Exploration, bibRecord, 001060

Allostatic load is associated with psychotic symptoms and decreases with antipsychotic treatment in patients with schizophrenia and first-episode psychosis.

Identifieur interne : 001060 ( Main/Exploration ); précédent : 001059; suivant : 001061

Allostatic load is associated with psychotic symptoms and decreases with antipsychotic treatment in patients with schizophrenia and first-episode psychosis.

Auteurs : Maximus Berger [Australie] ; Robert-Paul Juster [États-Unis] ; Sabine Westphal [Allemagne] ; G Paul Amminger [Australie] ; Bernhard Bogerts [Allemagne] ; Kolja Schiltz [Allemagne] ; Sabine Bahn [Royaume-Uni] ; Johann Steiner [Allemagne] ; Zoltan Sarnyai [Australie]

Source :

Psychoneuroendocrinology [ 1873-3360 ] ; 2018.

RBID : pubmed:29427955

Descripteurs français

KwdFr :
- Adulte (MeSH), Allostasie (effets des médicaments et des substances chimiques), Allostasie (physiologie), Femelle (MeSH), Humains (MeSH), Marqueurs biologiques (métabolisme), Mâle (MeSH), Neuroleptiques (administration et posologie), Schizophrénie (métabolisme), Schizophrénie (traitement médicamenteux), Troubles psychotiques (métabolisme), Troubles psychotiques (traitement médicamenteux), Échelles d'évaluation en psychiatrie (MeSH).
MESH :
- administration et posologie : Neuroleptiques.
- effets des médicaments et des substances chimiques : Allostasie.
- métabolisme : Marqueurs biologiques, Schizophrénie, Troubles psychotiques.
- physiologie : Allostasie.
- traitement médicamenteux : Schizophrénie, Troubles psychotiques.
- Adulte, Femelle, Humains, Mâle, Échelles d'évaluation en psychiatrie.

English descriptors

KwdEn :
- Adult (MeSH), Allostasis (drug effects), Allostasis (physiology), Antipsychotic Agents (administration & dosage), Biomarkers (metabolism), Female (MeSH), Humans (MeSH), Male (MeSH), Psychiatric Status Rating Scales (MeSH), Psychotic Disorders (drug therapy), Psychotic Disorders (metabolism), Schizophrenia (drug therapy), Schizophrenia (metabolism).
MESH :
- chemical , administration & dosage : Antipsychotic Agents.
- drug effects : Allostasis.
- drug therapy : Psychotic Disorders, Schizophrenia.
- chemical , metabolism : Biomarkers, Psychotic Disorders, Schizophrenia.
- physiology : Allostasis.
- Adult, Female, Humans, Male, Psychiatric Status Rating Scales.

Abstract

Current pathophysiological models of schizophrenia suggest that stress contributes to the etiology and trajectory of the disorder. We investigated if allostatic load (AL), an integrative index of neuroendocrine, immune and metabolic dysregulation in response to chronic stress, is elevated in patients with schizophrenia (SCZ) and first-episode psychosis (FEP) and related to psychotic symptoms and social and occupational functioning. Additionally, we assessed the temporal dynamics of AL in response to treatment with second-generation antipsychotics. AL, psychotic symptoms and psychosocial functioning were assessed in a longitudinal design in patients with SCZ (n = 28), FEP (n = 28), and healthy controls (n = 53) at baseline and 6 and 12 weeks after commencement of antipsychotic therapy. AL at baseline was higher in patients with SCZ and FEP relative to controls, but not different between patients with SCZ and FEP. Adjusting for age and smoking, we found that positive symptoms were positively correlated with AL and psychosocial functioning was negatively correlated with AL at trend level. Linear mixed model analysis demonstrated that AL decreased after treatment was commenced in patients with SCZ and FEP between the baseline assessment and the 6 and 12-week follow-up. AL was not predictive of treatment response or symptomatic remission. Our data provide evidence for cumulative physiological dysregulation in patients with SCZ and FEP that is linked to the experience of current positive psychotic symptoms. AL could be a useful tool to monitor biological signatures related to chronic stress and unhealthy behaviors in schizophrenia.

DOI: 10.1016/j.psyneuen.2018.02.001
PubMed: 29427955

Affiliations:

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Le document en format XML

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<term>Allostasis (drug effects)</term>
<term>Allostasis (physiology)</term>
<term>Antipsychotic Agents (administration & dosage)</term>
<term>Biomarkers (metabolism)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Psychiatric Status Rating Scales (MeSH)</term>
<term>Psychotic Disorders (drug therapy)</term>
<term>Psychotic Disorders (metabolism)</term>
<term>Schizophrenia (drug therapy)</term>
<term>Schizophrenia (metabolism)</term>
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<term>Allostasie (effets des médicaments et des substances chimiques)</term>
<term>Allostasie (physiologie)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Marqueurs biologiques (métabolisme)</term>
<term>Mâle (MeSH)</term>
<term>Neuroleptiques (administration et posologie)</term>
<term>Schizophrénie (métabolisme)</term>
<term>Schizophrénie (traitement médicamenteux)</term>
<term>Troubles psychotiques (métabolisme)</term>
<term>Troubles psychotiques (traitement médicamenteux)</term>
<term>Échelles d'évaluation en psychiatrie (MeSH)</term>
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</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Psychotic Disorders</term>
<term>Schizophrenia</term>
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<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Allostasie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term>
<term>Psychotic Disorders</term>
<term>Schizophrenia</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Marqueurs biologiques</term>
<term>Schizophrénie</term>
<term>Troubles psychotiques</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Allostasie</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Allostasis</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Schizophrénie</term>
<term>Troubles psychotiques</term>
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<term>Femelle</term>
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<front><div type="abstract" xml:lang="en">Current pathophysiological models of schizophrenia suggest that stress contributes to the etiology and trajectory of the disorder. We investigated if allostatic load (AL), an integrative index of neuroendocrine, immune and metabolic dysregulation in response to chronic stress, is elevated in patients with schizophrenia (SCZ) and first-episode psychosis (FEP) and related to psychotic symptoms and social and occupational functioning. Additionally, we assessed the temporal dynamics of AL in response to treatment with second-generation antipsychotics. AL, psychotic symptoms and psychosocial functioning were assessed in a longitudinal design in patients with SCZ (n = 28), FEP (n = 28), and healthy controls (n = 53) at baseline and 6 and 12 weeks after commencement of antipsychotic therapy. AL at baseline was higher in patients with SCZ and FEP relative to controls, but not different between patients with SCZ and FEP. Adjusting for age and smoking, we found that positive symptoms were positively correlated with AL and psychosocial functioning was negatively correlated with AL at trend level. Linear mixed model analysis demonstrated that AL decreased after treatment was commenced in patients with SCZ and FEP between the baseline assessment and the 6 and 12-week follow-up. AL was not predictive of treatment response or symptomatic remission. Our data provide evidence for cumulative physiological dysregulation in patients with SCZ and FEP that is linked to the experience of current positive psychotic symptoms. AL could be a useful tool to monitor biological signatures related to chronic stress and unhealthy behaviors in schizophrenia.</div>
</front>
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<Abstract><AbstractText>Current pathophysiological models of schizophrenia suggest that stress contributes to the etiology and trajectory of the disorder. We investigated if allostatic load (AL), an integrative index of neuroendocrine, immune and metabolic dysregulation in response to chronic stress, is elevated in patients with schizophrenia (SCZ) and first-episode psychosis (FEP) and related to psychotic symptoms and social and occupational functioning. Additionally, we assessed the temporal dynamics of AL in response to treatment with second-generation antipsychotics. AL, psychotic symptoms and psychosocial functioning were assessed in a longitudinal design in patients with SCZ (n = 28), FEP (n = 28), and healthy controls (n = 53) at baseline and 6 and 12 weeks after commencement of antipsychotic therapy. AL at baseline was higher in patients with SCZ and FEP relative to controls, but not different between patients with SCZ and FEP. Adjusting for age and smoking, we found that positive symptoms were positively correlated with AL and psychosocial functioning was negatively correlated with AL at trend level. Linear mixed model analysis demonstrated that AL decreased after treatment was commenced in patients with SCZ and FEP between the baseline assessment and the 6 and 12-week follow-up. AL was not predictive of treatment response or symptomatic remission. Our data provide evidence for cumulative physiological dysregulation in patients with SCZ and FEP that is linked to the experience of current positive psychotic symptoms. AL could be a useful tool to monitor biological signatures related to chronic stress and unhealthy behaviors in schizophrenia.</AbstractText>
<CopyrightInformation>Copyright © 2018 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Berger</LastName>
<ForeName>Maximus</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine (AITHM), 1 James Cook Drive, Townsville, QLD, 4811, Australia, Australia; College of Public Health, Medical and Veterinary Science, James Cook University, 1 James Cook Drive, Townsville, QLD, 4811, Australia; Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Rd, Parkville, VIC, 3052, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Juster</LastName>
<ForeName>Robert-Paul</ForeName>
<Initials>RP</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Columbia University Medical Center, Columbia University, 3960 Broadway, New York, NY, 10032, United States.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Westphal</LastName>
<ForeName>Sabine</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Institute of Clinical Chemistry and Pathobiochemistry, University of Magdeburg, Leipziger Str. 44, Magdeburg, D-39120, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Amminger</LastName>
<ForeName>G Paul</ForeName>
<Initials>GP</Initials>
<AffiliationInfo><Affiliation>Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Rd, Parkville, VIC, 3052, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bogerts</LastName>
<ForeName>Bernhard</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of Magdeburg, Leipziger Str. 44, Magdeburg, D-39120, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schiltz</LastName>
<ForeName>Kolja</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Forensic Psychiatry, Psychiatric Hospital of the Ludwig-Maximilians-University München, Nußbaumstr. 7, D-80336, München, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bahn</LastName>
<ForeName>Sabine</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Steiner</LastName>
<ForeName>Johann</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of Magdeburg, Leipziger Str. 44, Magdeburg, D-39120, Germany. Electronic address: johann.steiner@med.ovgu.de.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sarnyai</LastName>
<ForeName>Zoltan</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine (AITHM), 1 James Cook Drive, Townsville, QLD, 4811, Australia, Australia; College of Public Health, Medical and Veterinary Science, James Cook University, 1 James Cook Drive, Townsville, QLD, 4811, Australia. Electronic address: zoltan.sarnyai@jcu.edu.au.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>02</Month>
<Day>05</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Psychoneuroendocrinology</MedlineTA>
<NlmUniqueID>7612148</NlmUniqueID>
<ISSNLinking>0306-4530</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014150">Antipsychotic Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D052636" MajorTopicYN="N">Allostasis</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014150" MajorTopicYN="N">Antipsychotic Agents</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011569" MajorTopicYN="N">Psychiatric Status Rating Scales</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011618" MajorTopicYN="N">Psychotic Disorders</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012559" MajorTopicYN="N">Schizophrenia</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Allostatic load</Keyword>
<Keyword MajorTopicYN="Y">Biomarkers</Keyword>
<Keyword MajorTopicYN="Y">First-episode psychosis</Keyword>
<Keyword MajorTopicYN="Y">Hpa-axis</Keyword>
<Keyword MajorTopicYN="Y">Schizophrenia</Keyword>
<Keyword MajorTopicYN="Y">Treatment outcomes</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>11</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>01</Month>
<Day>28</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>02</Month>
<Day>01</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>2</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>1</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>2</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29427955</ArticleId>
<ArticleId IdType="pii">S0306-4530(17)31550-0</ArticleId>
<ArticleId IdType="doi">10.1016/j.psyneuen.2018.02.001</ArticleId>
</ArticleIdList>
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</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Bavière</li>
<li>District de Haute-Bavière</li>
<li>Saxe-Anhalt</li>
</region>
<settlement><li>Cambridge</li>
<li>Magdebourg</li>
<li>Munich</li>
</settlement>
<orgName><li>Université de Cambridge</li>
</orgName>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Berger, Maximus" sort="Berger, Maximus" uniqKey="Berger M" first="Maximus" last="Berger">Maximus Berger</name>
</noRegion>
<name sortKey="Amminger, G Paul" sort="Amminger, G Paul" uniqKey="Amminger G" first="G Paul" last="Amminger">G Paul Amminger</name>
<name sortKey="Sarnyai, Zoltan" sort="Sarnyai, Zoltan" uniqKey="Sarnyai Z" first="Zoltan" last="Sarnyai">Zoltan Sarnyai</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Juster, Robert Paul" sort="Juster, Robert Paul" uniqKey="Juster R" first="Robert-Paul" last="Juster">Robert-Paul Juster</name>
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</country>
<country name="Allemagne"><region name="Saxe-Anhalt"><name sortKey="Westphal, Sabine" sort="Westphal, Sabine" uniqKey="Westphal S" first="Sabine" last="Westphal">Sabine Westphal</name>
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<name sortKey="Bogerts, Bernhard" sort="Bogerts, Bernhard" uniqKey="Bogerts B" first="Bernhard" last="Bogerts">Bernhard Bogerts</name>
<name sortKey="Schiltz, Kolja" sort="Schiltz, Kolja" uniqKey="Schiltz K" first="Kolja" last="Schiltz">Kolja Schiltz</name>
<name sortKey="Steiner, Johann" sort="Steiner, Johann" uniqKey="Steiner J" first="Johann" last="Steiner">Johann Steiner</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Bahn, Sabine" sort="Bahn, Sabine" uniqKey="Bahn S" first="Sabine" last="Bahn">Sabine Bahn</name>
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   |texte=   Allostatic load is associated with psychotic symptoms and decreases with antipsychotic treatment in patients with schizophrenia and first-episode psychosis.
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Allostatic load is associated with psychotic symptoms and decreases with antipsychotic treatment in patients with schizophrenia and first-episode psychosis.

Allostatic load is associated with psychotic symptoms and decreases with antipsychotic treatment in patients with schizophrenia and first-episode psychosis.

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